The data was analyzed with the independent t-test. Effectiveness was assessed by comparing the duration of phototherapy, bilirubin reduction rate and side effects of treatment. Thirteen (13) neonates were allocated to receive fiberoptic phototherapy, 13 to blue light conventional phototherapy and 15 to white light conventional phototherapy.
A total of 41 term neonates, less than 7 days of age with unconjugated hyperbilirubinemia were randomized.
#Pathological jaundice trial
This was a randomized controlled trial conducted at the Kilimanjaro Christian Medical Centre (KCMC). Our study aimed to compare the effectiveness of fiberoptic phototherapy with a larger illuminated area and higher irradiance to conventional phototherapy methods. Over recent years, several studies reported fiberoptic phototherapy to be less effective than conventional phototherapy in term neonates. Effective treatment of jaundice requires therapeutic intervention with high quality phototherapy. Neonatal jaundice is one of the most common problems in neonates.
Neonatal jaundice can be treated using phototherapy, pharmacological agents, intravenous immunoglobulins and exchange transfusion in severe cases. Therefore, early diagnosis and management is essential. However, some severe cases may progress to develop severe and permanent long-term complications. Most cases of neonatal hyperbilirubinemia and jaundice are physiological and benign. Hyperbilirubinemia and jaundice are common issues encountered neonates and infants. The following search terms were used: neonatal jaundice, hyperbilirubinemia, ABO incompatibility, neonatal hemolysis, kernicterus, phototherapy, exchange transfusion. We conducted this review using a comprehensive search of MEDLINE, PubMed and EMBASE from January 2001 to March 2017. We tried to understand the various types of neonatal jaundice, and also focus on its management. Neonatal jaundice can be classified as physiological and pathological and can have several causes such as breast milk feeding, blood group incompatibility, hemolysis, or genetic defects of enzymes in the bilirubin metabolism pathway. 80% of healthy neonates present with some degree of hyperbilirubinemia after birth, however, only 5-10% would require therapy to prevent damage or treat the cause of jaundice.
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